Abstract  Product information sheet, MSDS, and Toxicity Data Summaries: acute oral rats, acute dermal rabbits, primary skin irritation rabbits, eye irritation rabbits, acute inhalation rats, Ames test, acute fish toxicity test, pilot cataractogenic study in chicks, cataractogenic study in chicks, biodegradation, hydrolysis, partition coefficient, solubility,

Abstract  Notice of initiation of 28-day repeated dose oral toxicity study of HBCD in rats

Abstract  Notice of initiation of a maximization test in guinea pigs and chromosomal aberrations in human peripheral blood

Abstract  The highly conserved nature of the thyroid gland and the thyroid system among mammalian species suggests it is critical to species survival. Studies show the thyroid system plays a critical role in the development of several organ systems, including the reproductive tract. Despite its highly conserved nature, the thyroid system can have widely different effects on reproduction and reproductive tract development in different species. The present review focuses on assessing the role of thyroid hormones in human reproduction and reproductive tract development and comparing it to the role of thyroid hormones in laboratory animal reproduction and reproductive tract development. The review also assesses the effects of thyroid dysfunction on reproductive tract development and function in humans and laboratory animals. Consideration of such information is important in designing, conducting, and interpreting studies to assess the potential effects of thyroid toxicants on reproduction and development.

Abstract  Final report of a 90-day oral gavage toxicity study in rats (converted from 8EHQ-0102-15040A) / A 90-Day Oral (Gavage) Toxicity Study of HBCD in Rats

Abstract  Hexabromocyclododecane was evaluated for mutagenicity by plate assay in the bacterium, Salmonella typhimurium, strains TA1535, TA1537, TA98, and TA100, both in the presence and absence of Aroclor 1254-induced rat liver homogenate. Positive (substance not identified), solvent (acetone), and untreated controls were utilized. Test concentrations ranged from 0.05 to 5.0 mg/plate. The high dose did not produce toxicity in any strain. A dose-related increase was observed in the number of revertant colonies in strains TA100 and TA1535 both in the presence and absence of metabolic activation.

Abstract  Hexabromocyclododecane (Compound 421-32B) was evaluated for mutagenicity by plate assay in two microorganisms, Saccharomyces cerevisiae, strain D4, and Salmonella typhimurium, strains TA1535, TA1537, TA1538, TA98, and TA100, both in the presence and absence of Aroclor 1254-induced rat liver homogenate. Positive (MNNG, NF, QM, ANTH, AAF, AMQ, and DMNA) and solvent (DMSO) controls were utilized. Test concentrations ranged from 0.5 to 50 ug/plate; the low dose was less than that which demonstrated any toxic effect, and the high dose produced quantitative or qualitative evidence of some chemically-induced physiological effects. No evidence of mutagenic activity from hexabromocyclododecane was seen in any of the assays conducted in this evaluation.

Abstract  1,2,5,6,9,10-Hexabromocyclododecane was evaluated for mutagenicity in vitro in the TA98, TA100, and TA1537 strains of Salmonella typhimurium, both in the presence and absence of Arochlor-induced rat liver S-9 metabolic activation. Bacterial cultures without metabolic activation were tested at concentrations of 0.0, 31.5, 100, 315, 1000, or 3000 ug/plate; bacterial cultures with metabolic activation were tested at 0, 3.15, 10, 31.5, 100, 315, 1000, and 3000 ug/plate; the test compound formed a precipitate at concentrations greater than 1000 ug/plate, possibly affecting the accuracy of the test. Some aromatic and olefinic compounds are metabolized to mutagenic epoxides; epoxides can be inactivated by epoxide hydratase or by conjugation to glutathione. A second trial was performed in TA98 with the same concentrations of test compound and with the addition of 1,1,1-trichloropropene 2,3-oxide, an inhibitor of epoxide hydratase and glutathione, to increase the sensitivity of the test towards compounds activated to mutagenic epoxides. The treatment did not increase the frequency of histidine revertants, either with or without metabolic activation, indicating that the test compound was negative for mutagenicity in Salmonella under the conditions of this assay. Positive control treatment with 10 ug/plate benzo(a)pyrene, 10 ug/plate 2-aminoanthracene, or 90 ug/plate 3methylcholanthrene (without activation) and 1 ug/plate benzo(a)pyrene 4,5-oxide or 10 ug/plate N-methyl-N'-nitro-Nnitrosoguanidine (with activation) produced the expected large increases in the frequency of histidine revertants.

Abstract  Material safety data sheets on hexabromocyclododecane and pentabromodiphenyloxide

Abstract  positive for genotoxicity in this cell culture assay.

Abstract  Three male and 3 female New Zealand White rabbits (obtained from Sweetwater Farms, Hillsboro, Ohio) were used for this study. The rabbits weight from 2510 to 3305 grams at the beginning of the study. The rabbits were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters. They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.I.H.) entitled 'Guide for the Care and Use of Laboratory Animals.' Water and Purina Rabbit Chow were available ad libitum.

Abstract  Addendum to HBCD 90 day oral (gavage) toxicity study in rats (initial submission); submission also includes final reports for TBBPA: activated sludge respiration test and a toxicity test to determine effects on seedling emergence in six plant species with TBBPA

Abstract  Response to EPA comments concerning the conclusions of a 90-day oral gavage toxicity study submitted earlier.