Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals
Krieger, RI; Bernard, CE; Dinoff, TM; Fell, L; Osimitz, TG; Ross, JH; Ongsinthusak, T
HERO ID
1060443
Reference Type
Journal Article
Year
2000
Language
English
PMID
| HERO ID | 1060443 |
|---|---|
| In Press | No |
| Year | 2000 |
| Title | Biomonitoring and whole body cotton dosimetry to estimate potential human dermal exposure to semivolatile chemicals |
| Authors | Krieger, RI; Bernard, CE; Dinoff, TM; Fell, L; Osimitz, TG; Ross, JH; Ongsinthusak, T |
| Journal | Journal of Exposure Analysis and Environmental Epidemiology |
| Volume | 10 |
| Issue | 1 |
| Page Numbers | 50-57 |
| Abstract | Current methods of estimating absorbed dosage (AD) of chemicals were evaluated to determine residue transfer from a carpet treated with chlorpyrifos (CP) to humans who performed a structured exercise routine. To determine the dislodgeability of residue, a California Department of Food and Agriculture (CDFA) roller was applied to a flat cotton cloth upon a treated carpet. Levels ranged from 0.06 to 0.99 microg CP/cm2. Cotton whole body dosimeters (WBD) were also used to assess residue transfer. The dosimeters retained 1.5 to 38 mg CP/person. Urine biomonitoring (3 days) for 3,5,6-trichloro-2-pyridinol (TCP) of persons who wore only swimsuits revealed a mean AD of 176 microg CP equivalents/person. The results show that the AD depends on the extent of contact transfer and dermal absorption of the residue. Default exposure assessments based upon environmental levels of chemicals and hypothetical transport pathways predict excessive exposure. The cotton WBD retains chemical residues and may be effectively used to predict dermal dose under experimental conditions. |
| Doi | 10.1038/sj.jea.7500072 |
| Pmid | 10703847 |
| Wosid | WOS:000087806600005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |