Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke

Hecht, SS

HERO ID

1070125

Reference Type

Journal Article

Subtype

Review

Year

2004

Language

English

PMID

14985617

HERO ID 1070125
Material Type Review
In Press No
Year 2004
Title Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke
Authors Hecht, SS
Journal Tobacco Control
Volume 13 Suppl 1
Issue SUPPL. 1
Page Numbers i48-i56
Abstract <strong>OBJECTIVE: </strong>To review the literature on carcinogen derived biomarkers of exposure to secondhand tobacco smoke (SHS). These biomarkers are specifically related to known carcinogens in tobacco smoke and include urinary metabolites, DNA adducts, and blood protein adducts.<br /><br /><strong>METHOD: </strong>Published reviews and the current literature were searched for relevant articles.<br /><br /><strong>RESULTS: </strong>The most consistently elevated biomarker in people exposed to SHS was 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (NNAL-Gluc), urinary metabolites of the tobacco specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The tobacco specificity of this biomarker as well as its clear relation to an established lung carcinogen are particularly appropriate for its application in studies of SHS exposure.<br /><br /><strong>CONCLUSION: </strong>The results of the available carcinogen derived biomarker studies provide biochemical data which support the conclusion, based on epidemiologic investigations, that SHS causes lung cancer in non-smokers.
Doi 10.1136/tc.2002.002816
Pmid 14985617
Wosid WOS:000220255900009
Is Certified Translation No
Dupe Override No
Comments Source: Web of Science WOS:000220255900009Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-7644242996&doi=10.1136%2ftc.2002.002816&partnerID=40&md5=39f98caa2f947d9028306c60cba77c7d
Is Public Yes
Language Text English
Is Qa No
Tags
IRIS
Benzo(a)pyrene (BaP)
  Considered