Relevant animal model of human lymphoblastic leukaemia/lymphoma--spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub)
Otová, B; Sladká, M; Damoiseaux, J; Panczak, A; Mandys, V; Marinov, I
| HERO ID | 1104567 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2002 |
| Title | Relevant animal model of human lymphoblastic leukaemia/lymphoma--spontaneous T-cell lymphomas in an inbred Sprague-Dawley rat strain (SD/Cub) |
| Authors | Otová, B; Sladká, M; Damoiseaux, J; Panczak, A; Mandys, V; Marinov, I |
| Journal | Folia Biologica (Prague) |
| Volume | 48 |
| Issue | 6 |
| Page Numbers | 213-226 |
| Abstract | More than a decade of experimental work in an inbred subline of Sprague-Dawley rats having high incidence of spontaneous T-cell lymphoma/leukaemia is reviewed. Longitudinal follow-up of biological characteristics (growth, survival, haematology) of both multiple cases of primary disease and s.c. passaged lymphomas as well as comparative immunophenotypic and karyotypic studies are concluded. In these T-cell lymphomas (mostly CD4 positive), arising on the same genetic background of the inbred SD strain, the aberrations involving chromosome 11 have been recognized as a typical non-random cytogenetic marker. This unique rat model of lymphoblastic lymphomas/leukaemias, relevant to human pathology, seems to be very suitable for testing different anticancer therapeutic strategies, as it is documented by results of a number of various protocols conducted in our laboratory. |
| Pmid | 12512796 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |