Health assessment document for trichloroethylene: External review draft
HERO ID
1137392
Reference Type
Technical Report
Subtype
EPA Report
Year
1983
| HERO ID | 1137392 |
|---|---|
| Material Type | EPA Report |
| Year | 1983 |
| Title | Health assessment document for trichloroethylene: External review draft |
| Authoring Organization | U.S. Environmental Protection Agency |
| Publisher Text | U.S. Environmental Protection Agency |
| City | Research Triangle Park, NC |
| Abstract | Trichloroethylene (TCI) is a member of a family of unsaturated chlorinated aliphatic compounds. Trichloroethylene, though a water and solid waste contaminant, is primarily of interest in situations involving ambient air exposure. It is released into ambient air as a result of evaporative losses during production, storage, and/or use. It has no known natural sources. It is photochemically reactive in the troposphere and is removed by scavenging mechanisms, principally via hydroxyl radicals. The scientific data base concerning the effects of TCI on humans is limited. Effects on humans have generally been ascertained from studies involving individuals occupationally or accidentally exposed. During such exposures, the concentrations associated with adverse effects on human health were either unknown or far in excess of concentrations found or expected in ambient air. Controlled TCI exposure studies have been directed toward elucidating the effects on the CNS, effects on clinical chemistries, and pharmacokinetic parameters of TCI exposure. The available epidemiologic studies have not been able to adequately assess the overall impact of TCI on human health. It has therefore been necessary to rely greatly on animal studies to derive indications of potential harmful effects. Although animal data cannot always be extrapolated to humans, indications of probable or likely effects in animal species increase confidence that similar effects may occur in humans. This document is intended to provide an evaluation of the scientific data base concerning TCI. The publications cited in this document represent a majority of the known scientific references to TCI. Reports which had little or no bearing on the issues discussed were not cited. Some topic areas, such as effects on terrestrial ecosystems, are only briefly discussed. Such topics reflect the nature of the scientific data base. On-going literature searches have been conducted through 1985, resulting in the inclusion of selected references in this document. However, the basic literature search for Chapter 8 is current through 1982; the basic literature search for Chapter 7 is current through 1983. The Agency is aware of additional carcinogenicity and mutagenicity information that has subsequently become available. This information will be considered for incorporation in any future updates of this document. |
| Report Number | EPA/600/8-82/006B |
| Url | http://nepis.epa.gov/Exe/ZyPURL.cgi?Dockey=2000BF41.txt |
| Is Certified Translation | No |
| Dupe Override | No |
| Number Of Pages | 318 |
| Is Public | Yes |
| Is Qa | No |
| Relationship(s) |
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