A Bayesian benchmark concentration analysis for urinary fluoride and intelligence in adults in Guizhou, China
HERO ID
12038616
Reference Type
Journal Article
Year
2024
Language
English
PMID
| HERO ID | 12038616 |
|---|---|
| In Press | No |
| Year | 2024 |
| Title | A Bayesian benchmark concentration analysis for urinary fluoride and intelligence in adults in Guizhou, China |
| Authoring Organization | State University of New York |
| Journal | Science of the Total Environment |
| Volume | 925 |
| Page Numbers | 171326 |
| Abstract | Environmental fluoride exposure has been linked to numerous cases of fluorosis worldwide. Previous studies have indicated that long-term exposure to fluoride can result in intellectual damage among children. However, a comprehensive health risk assessment of fluorosis-induced intellectual damage is still pending. In this research, we utilized the Bayesian Benchmark Dose Analysis System (BBMD) to investigate the dose-response relationship between urinary fluoride (U-F) concentration and Raven scores in adults from Nayong, Guizhou, China. Our research findings indecate a dose-response relationship between the concentration of U-F and intelligence scores in adults. As the benchmark response (BMR) increased, both the benchmark concentration (BMCs) and the lower bound of the credible interval (BMCLs) increased. Specifically, BMCs for the association between U-F and IQ score were determined to be 0.18 mg/L (BMCL(1) = 0.08 mg/L), 0.91 mg/L (BMCL(5) = 0.40 mg/L), 1.83 mg/L (BMCL(10) = 0.83 mg/L) when using BMRs of 1 %, 5 %, and 10 %. These results indicate that U-F can serve as an effective biomarker for monitoring the loss of IQ in population. We propose three interim targets for public policy in preventing interllectual harm from fluoride exposure. |
| Doi | 10.1016/j.scitotenv.2024.171326 |
| Pmid | 38460703 |
| Wosid | WOS:001221911900001 |
| Url | https://www.ncbi.nlm.nih.gov/pubmed/38460703 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Child Adult Humans *Fluorides/analysis *Fluorosis, Dental/epidemiology Benchmarking Bayes Theorem Intelligence China/epidemiology Bmc Bayesian estimation Health risk assessment Urinary fluoride concentration |