Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats
Lington, AW; Bird, MG; Plutnick, RT; Stubblefield, WA; Scala, RA
HERO ID
1239588
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 1239588 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Chronic toxicity and carcinogenic evaluation of diisononyl phthalate in rats |
| Authors | Lington, AW; Bird, MG; Plutnick, RT; Stubblefield, WA; Scala, RA |
| Journal | Fundamental and Applied Toxicology |
| Volume | 36 |
| Issue | 1 |
| Page Numbers | 79-89 |
| Abstract | Groups of 110 Fischer 344 rats/sex were fed diisononyl phthalate (DINP) at dietary levels of 0, 0.03, 0.3, and 0.6 wt% for periods up to 2 years. Interim sacrifices of 10 predesignated rats/sex/dose were at 6, 12, and 18 months with surviving animals sacrificed at 24 months. At study termination, survival was in excess of 60% for every group. At the mid or high dose, the following biological effects were noted: slight decreases in food consumption and body weight; slight increase in mortality; a dose-related increase in relative organ weights of liver and kidney; and some slight effects on urinalysis, hematologic, and clinical chemistry parameters. No peroxisome induction was observed in livers of treated rats compared with controls. No clear treatment-related nonneoplastic or neoplastic lesions were found. However, mononuclear cell leukemia (MNCL) and changes known to be associated with an increased incidence of MNCL were seen in the mid-dose and high-dose groups. A literature review suggests that MNCL is a common finding in aging F344 rats and that this increased incidence in rats treated with DINP is not relevant to man. A clear no-observed-effect level was demonstrated for all biological end points at a dietary level of 0. 03 wt% or approximately 17 mg/kg/day of DINP. |
| Doi | 10.1093/toxsci/36.1.79 |
| Pmid | 9073470 |
| Wosid | WOS:A1997WP30200009 |
| Url | http://www.sciencedirect.com/science/article/pii/S0272059097922867 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Phthalic Acids; diisononyl phthalate; 4010KIX4CK; Index Medicus; Testis -- drug effects; Body Weight -- drug effects; Blood Chemical Analysis; Administration, Oral; Rats, Inbred F344; Spleen -- drug effects; Survival Rate; Hematologic Tests; Precancerous Conditions -- pathology; Carcinogenicity Tests; Adrenal Glands -- drug effects; Microbodies -- drug effects; No-Observed-Adverse-Effect Level; Animals; Urine -- chemistry; Leukemia, Experimental -- pathology; Leukemia, Experimental -- chemically induced; Organ Size -- drug effects; Spleen -- pathology; Adrenal Glands -- pathology; Liver -- drug effects; Kidney -- pathology; Kidney -- drug effects; Phthalic Acids -- toxicity; Liver -- pathology |
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