A review: Hemodynamic response to carbon monoxide
Penney, DG
HERO ID
12519
Reference Type
Journal Article
Subtype
Review
Year
1988
Language
English
PMID
| HERO ID | 12519 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 1988 |
| Title | A review: Hemodynamic response to carbon monoxide |
| Authors | Penney, DG |
| Journal | Environmental Health Perspectives |
| Volume | 77 |
| Issue | 0 |
| Page Numbers | 121-130 |
| Abstract | Historically, and at present, carbon monoxide is a major gaseous poison responsible for widespread morbidity and mortality. From threshold to maximal nonlethal levels, a variety of cardiovascular changes occur, both immediately and in the long term, whose homeostatic function it is to renormalize tissue oxygen delivery. However, notwithstanding numerous studies over the past century, the literature remains equivocal regarding the hemodynamic responses in animals and humans, although CO hypoxia is clearly different in several respects from hypoxic hypoxia. Factors complicating interpretation of experimental findings include species, CO dose level and rate, route of CO delivery, duration, level of exertion, state of consciousness, and anesthetic agent used. For example, tachycardia is commonly observed, although bradycardia also can result from myocardial and/or central nervous system (CNS) hypoxemia at high carboxyhemoglobin (COHb) saturations, as can electrocardiographic abnormalities. Augmented cardiac output usually observed with moderate COHb may be compromised in more severe poisoning for the same reasons, such that regional or global ischemia result. The hypotension usually seen in most animal studies is thought to be a primary cause of CNS damage resulting from acute CO poisoning, yet the exact mechanism(s) remains unproven in both animals and humans, as does the way in which CO produces hypotension. This review briefly summarizes the literature relevant to the short- and long-term hemodynamic responses reported in animals and humans. It concludes by presenting an overview using data from a single species in which the most complete work has been done to date. |
| Doi | 10.2307/3430637 |
| Pmid | 3289904 |
| Wosid | WOS:A1988N537300017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Environ. Health Perspect 77: 121-130. |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |