Maximal aerobic capacity at several ambient concentrations of carbon monoxide at several altitudes
Horvath, SM; Bedi, JF; Wagner, JA; Agnew, JW
HERO ID
12725
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 12725 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Maximal aerobic capacity at several ambient concentrations of carbon monoxide at several altitudes |
| Authors | Horvath, SM; Bedi, JF; Wagner, JA; Agnew, JW |
| Journal | Journal of Applied Physiology (1985) |
| Volume | 65 |
| Issue | 6 |
| Page Numbers | 2696-2708 |
| Abstract | To assests the nature of the combined effect of the hypoxias of altitude (ALT) and CO exposure, 11 men and 12 women non-smokers served as subjects in a doubleblind experiment. The exposure conditions were four ambient CO levels (0, 50, 100, and 150 ppm) at each of four ALT (55, 1,524, 2,134, and 3,048 m). Each subject, after attaining the required ALT and ambient CO level, performed a maximal aerobic capacity test (VO zmax). Blood samples were obtained before, at 50-W, 100-W, 150-W, and maximum work loads and at the 5th min of recovery. Blood were analyzed for hemoglobin, hematocrit, plasma proteins, lactates, and carboxyhemoglobin (HbCO). VO zmax was similar at 55 and 1,524 m and decreased by 4 and 8% from the 55-m value at 2,134 and 3,048 m, respectively. On the basis of all statistical analyses, we concluded that VO2 max values measured in men were only slightly diminished due to increased ambient CO. HbCO attained at maximum was highest at 55 m and lowest at 3,048 m. Women?s HbCO concentrations were lower than men?s. At maximal work loads CO shifted into extravascular spaces and returned to the vascular space within 5 min after exercise stopped. The independence of altitude and CO hypoxias on parameters of the maximum aerobic capacity test and a decrease in the CO to HbCO uptake with increasing altitude were demonstrated and attributed in part to the decreasein driving pressure of CO at altitude. |
| Pmid | 3269259 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | 1988b in 073,01, 073,11, and 813,08.Cambridge, MA: Health Effects Institute; research report no. 21. |
| Is Public | Yes |
| Language Text | English |
| Keyword | carboxyhemoglobin; synergistic effect; carbon monoxide storage |
| Is Qa | No |