Human kidney methoxyflurane and sevoflurane metabolism
Kharasch, ED; Hankins, DC; Thummel, KE
HERO ID
12776
Reference Type
Journal Article
Year
1995
Language
English
PMID
| HERO ID | 12776 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Human kidney methoxyflurane and sevoflurane metabolism |
| Authors | Kharasch, ED; Hankins, DC; Thummel, KE |
| Journal | Anesthesiology |
| Volume | 82 |
| Issue | 3 |
| Page Numbers | 689-699 |
| Abstract | Conclusions: Human kidney microsomes metabolize methoxyflurane, and to a much lesser extent sevoflurane, to fluoride ion. P450s 2E1 and/or 2A6 and P450 3A are Implicated in the defluorinatlon. If intrarenally generated fluoride or other metabolites are nephrotoxic, then renal metabolism may contribute to methoxyflurane nephrotoxicity. The relative paucity of renal sevoflurane defluorinatlon may explain the absence of clinical sevoflurane nephrotoxicity to date, despite plasma fluoride concentrations that may exceed 50 "mu"m. |
| Doi | 10.1097/00000542-199503000-00011 |
| Pmid | 7879937 |
| Wosid | WOS:A1995QK90500012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. |
| Is Public | Yes |
| Language Text | English |
| Keyword | ANESTHETICS, VOLATILE, ENFLURANE ISOFLURANE METHOXYFLURANE SEVOFLURANE; IONS, FLUORIDE; KIDNEY, METABOLISM; LIVER, METABOLISM; METABOLISM, DRUG, CYTOCHROME P450; TOXICITY, FLUORIDE METABOLITES RENAL |
| Is Qa | No |