A marine sulfate-reducing bacterium producing multiple antibiotics: biological and chemical investigation
Zhang, Y; Mu, J; Gu, X; Zhao, C; Wang, X; Xie, Z
HERO ID
1323146
Reference Type
Journal Article
Year
2009
Language
English
PMID
| HERO ID | 1323146 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | A marine sulfate-reducing bacterium producing multiple antibiotics: biological and chemical investigation |
| Authors | Zhang, Y; Mu, J; Gu, X; Zhao, C; Wang, X; Xie, Z |
| Journal | Marine Drugs |
| Volume | 7 |
| Issue | 3 |
| Page Numbers | 341-354 |
| Abstract | A marine sulfate-reducing bacterium SRB-22 was isolated by means of the agar shake dilution method and identified as Desulfovibrio desulfuricans by morphological, physiological and biochemical characteristics and 16S rDNA analysis. In the bioassay, its extract showed broad-spectrum antimicrobial activity using the paper disc agar diffusion method. This isolate showed a different antimicrobial profile than either ampicillin or nystatin and was found to produce at least eight antimicrobial components by bioautography. Suitable fermentation conditions for production of the active constituents were determined to be 28 day cultivation at 25 degrees C to 30 degrees C with a 10% inoculation ratio. Under these conditions, the SRB-22 was fermented, extracted and chemically investigated. So far an antimicrobial compound, mono-n-butyl phthalate, and an inactive compound, thymine, have been isolated and characterized. |
| Doi | 10.3390/md7030341 |
| Pmid | 19841718 |
| Wosid | WOS:000270196400004 |
| Url | https://search.proquest.com/docview/1536059173?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | marine sulfate-reducing bacterium; isolation; identification; broad-spectrum antimicrobial activity; mono-n-butyl phthalate |