Mutagenicity and nitropyrene concentration of indoor air particulates exhausted from a kerosene heater
Kinouchi, T; Nishifuji, K; Tsutsui, H; Hoare, SL; Ohnishi, Y
HERO ID
1325404
Reference Type
Journal Article
Year
1988
Language
English
PMID
| HERO ID | 1325404 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Mutagenicity and nitropyrene concentration of indoor air particulates exhausted from a kerosene heater |
| Authors | Kinouchi, T; Nishifuji, K; Tsutsui, H; Hoare, SL; Ohnishi, Y |
| Journal | Japanese Journal of Cancer Research |
| Volume | 79 |
| Issue | 1 |
| Page Numbers | 32-41 |
| Abstract | The particulates in a room warmed with a radiant kerosene heater were collected, extracted and fractionated into diethyl ether-soluble neutral, acidic and basic fractions. The mutagenicity of these fractions was measured with Salmonella typhimurium strains TA98, TA98NR, TA98/1,8-DNP6 and TA100 in the presence and absence of S9 mix. Room air without the heater showed very low mutagenicity. However, a sample from a room at the beginning of the burning period showed very high mutagenicity (237 His+ revertants/plate/m3 of air in strain TA98 in the absence of S9 mix). In contrast, emissions from the heater after it was burning stably showed low mutagenicity (9 His+ revertants/plate/m3). The crude extract of particulates from the heater at the beginning of the burning period was analyzed by high-pressure liquid chromatography (HPLC) and showed a considerable amount of nitropyrenes (NPs); the concentrations of 1-NP and 1,6-diNP were 1.62 ng and 0.149 ng/m3 of air, respectively, and accounted for 1.2% and 17.6%, respectively, of the mutagenicity in strain TA98 in the absence of S9 mix. In addition, an HPLC-Ames histogram showed that peaks of mutagenicity corresponding to 1-NP and diNPs accounted for 75.7% (1-NP, 4.9%; 1,6-diNP, 17.1%; 1,8-diNP, 46.3%; 1,3-diNP, 7.4%) of the HPLC-recovered mutagenicity for strain TA98 without S9 mix. These results that kerosene heaters, especially immediately after ignition, create mutagenic substances such as NPs. |
| Doi | 10.1111/j.1349-7006.1988.tb00008.x |
| Pmid | 3128503 |
| Wosid | WOS:A1988M741700008 |
| Url | https://www.proquest.com/scholarly-journals/mutagenicity-nitropyrene-concentration-indoor-air/docview/78167553/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Air Pollutants; Kerosene; Mutagens; Petroleum; Pyrenes; 1,6-dinitropyrene; 66Q2ZUF83N; Nitrogen Dioxide; S7G510RUBH; 1-nitropyrene; TD1665I8Q4; Index Medicus; Nitrogen Dioxide -- analysis; Chromatography, High Pressure Liquid; Heating; Mutagens -- analysis; Pyrenes -- analysis; Air Pollutants -- analysis |
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