Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols
Harifi-Mood, AR; Haghighi, S; Gholami, MR
| HERO ID | 1400063 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Fluorometric variable-temperature kinetics investigations of the transesterification reaction of procaine with aliphatic alcohols |
| Authors | Harifi-Mood, AR; Haghighi, S; Gholami, MR |
| Journal | Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 7 |
| Issue | 1 |
| Page Numbers | 88-91 |
| Abstract | <strong>PURPOSE: </strong>Variable-Temperature Kinetics has been used to obtain the rate constants of the reaction at various temperatures during one kinetic run.<br /><br /><strong>METHODS: </strong>Pseudo-first-order rate constants for the transesterification of procaine with aliphatic alcohols ethanol, n-propanol and tert-butanol were obtained by the fluorescence spectroscopy using the variable-temperature kinetics (VTK) method.<br /><br /><strong>RESULTS: </strong>The activation parameters of the reactions were calculated (24-28 kcal x mol(-1)). The half-life of the procaine decreases in the ethanol solution compared with the other alcoholic solutions in the presence of sodium ethoxide.<br /><br /><strong>CONCLUSIONS: </strong>The investigation time of the reactions is reduced to one-tenth of the one used for usual kinetic methods. |
| Pmid | 15144741 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |