The metabolism of ceramic and non-ceramic forms of uranium dioxide after deposition in the rat lung
Stradling, GN; Stather, JW; Gray, SA; Moody, JC; Hodgson, A; Sedgwick, D; Cooke, N
| HERO ID | 1421033 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | The metabolism of ceramic and non-ceramic forms of uranium dioxide after deposition in the rat lung |
| Authors | Stradling, GN; Stather, JW; Gray, SA; Moody, JC; Hodgson, A; Sedgwick, D; Cooke, N |
| Journal | Human Toxicology |
| Volume | 7 |
| Issue | 2 |
| Page Numbers | 133-139 |
| Abstract | Ceramic and non-ceramic forms of uranium dioxide, produced industrially, were administered to rats either by inhalation or as an aqueous suspension which was injected directly into the pulmonary region of the lungs. The results showed that: 1 both materials should be assigned to inhalation class Y as defined by the International Commission on Radiological Protection; 2 whilst the translocation of uranium to the blood for the non-ceramic UO2 was about twice that obtained for the ceramic form, the two dioxides were unlikely to be differentiated on the basis of their lung retention kinetics; 3 the distribution of uranium amongst body tissues and the relationship between systemic content and cumulative urinary excretion indicated that it was transported in the hexavalent form; 4 in addition to air sampling procedures, lung radioactivity counting measurements could be used to advantage for assessing occupational exposures; 5 the exposure limits should be based on radiation dose rather than chemical toxicity. |
| Doi | 10.1177/096032718800700205 |
| Pmid | 3378801 |
| Wosid | WOS:A1988M487700005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1988M487700005 |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Radiation-Radiation Effects and Protective Measures</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Biochemical Studies-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Metabolism-Minerals</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Respiratory System-Pathology</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Public Health: Environmental Health-Occupational Health</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Public Health: Environmental Health-Radiation Health</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Hominidae</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Muridae</kw> |