Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles
Gong, H; Linn, WS; Terrell, SL; Clark, KW; Geller, MD; Anderson, KR; Cascio, WE; Sioutas, C
HERO ID
1453895
Reference Type
Journal Article
Year
2004
Language
English
PMID
| HERO ID | 1453895 |
|---|---|
| In Press | No |
| Year | 2004 |
| Title | Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles |
| Authors | Gong, H; Linn, WS; Terrell, SL; Clark, KW; Geller, MD; Anderson, KR; Cascio, WE; Sioutas, C |
| Journal | Inhalation Toxicology |
| Volume | 16 |
| Issue | 6-7 |
| Page Numbers | 335-343 |
| Abstract | Twelve mildly asthmatic and four healthy adults were exposed to filtered air (FA) and concentrated ambient coarse particles (CCP) supplied to a whole-body exposure chamber via a coarse particle concentrator with 15 parallel virtual impactors. Exposures were conducted in a Los Angeles suburb with high levels of motor-vehicle pollution and lasted 2 h with intermittent exercise. Mean CCP concentration was 157 microg/m(3) (range: 56-218 microg/m(3)) measured by continuous monitoring with a tapered-element oscillating microbalance (TEOM). On average, 80% of mass was coarse (2.5-10 microm aerodynamic diameter) and the rest <2.5 microm. Relative to FA, CCP exposure did not significantly alter respiratory symptoms, spirometry, arterial oxygen saturation, or airway inflammation according to exhaled nitric oxide and total and differential cell counts of induced sputum. After CCP exposure, Holter electrocardiograms showed small (p <.05) increases in heart rate and decreases in heart-rate variability, which were larger in healthy than in asthmatic subjects. Cardiac ectopy did not increase. In conclusion, acute exposure to elevated concentrations of ambient coarse particles elicited no obvious pulmonary effects but appeared to alter the autonomic nervous system of the heart in adult volunteers. |
| Doi | 10.1080/08958370490439470 |
| Pmid | 15204749 |
| Wosid | WOS:000221111100002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | ECRIB. 2004b in 1557,01.Inhalation Toxicol. 16: 335-343. |
| Is Public | Yes |
| Language Text | English |
| Keyword | Adult; Air Pollution/adverse effects; Asthma/physiopathology; Atmosphere Exposure Chambers; Electrocardiography, Ambulatory; Heart Rate; Inhalation Exposure/adverse effects; Los Angeles; Middle Aged; Oxygen/blood; Particle Size; Spirometry; Sputum/cytology; Suburban Population; Surveys and Questionnaires |
| Is Qa | No |
| Relationship(s) |
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