Long-term exposure to PM2.5 and incidence of acute myocardial infarction
Madrigano, J; Kloog, I; Goldberg, T; Coull, BA; Mittleman, MA; Schwartz, J
HERO ID
1453904
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 1453904 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Long-term exposure to PM2.5 and incidence of acute myocardial infarction |
| Authors | Madrigano, J; Kloog, I; Goldberg, T; Coull, BA; Mittleman, MA; Schwartz, J |
| Journal | Environmental Health Perspectives |
| Volume | 121 |
| Issue | 2 |
| Page Numbers | 192-196 |
| Abstract | Background: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association between long-term exposure to fine particulate air pollution and specific cardiovascular events, such as acute myocardial infarction (AMI). Objective: We examined how long-term exposure to area particulate matter affects the onset of AMI, and we distinguished between area and local pollutants. Methods: Building on the Worcester Heart Attack Study, an ongoing community-wide investigation examining changes over time in myocardial infarction incidence in greater Worcester, Massachusetts, we conducted a case–control study of 4,467 confirmed cases of AMI diagnosed between 1995 and 2003 and 9,072 matched controls selected from Massachusetts resident lists. We used a prediction model based on satellite aerosol optical depth (AOD) measurements to generate both exposure to particulate matter ≤ 2.5 μm in diameter (PM2.5) at the area level (10 × 10 km) and the local level (100 m) based on local land use variables. We then examined the association between area and local particulate pollution and occurrence of AMI. Results: An interquartile range (IQR) increase in area PM2.5 (0.59 μg/m3) was associated with a 16% increase in the odds of AMI (95% CI: 1.04, 1.29). An IQR increase in total PM2.5 (area + local, 1.05 μg/m3) was weakly associated with a 4% increase in the odds of AMI (95% CI: 0.96, 1.11). Conclusions: Residential exposure to PM2.5 may best be represented by a combination of area and local PM2.5, and it is important to consider spatial gradients within a single metropolitan area when examining the relationship between particulate matter exposure and cardiovascular events. |
| Doi | 10.1289/ehp.1205284 |
| Pmid | 23204289 |
| Wosid | WOS:000323700900020 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | air pollution |