Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children
Perera, FP; Wang, S; Vishnevetsky, J; Zhang, B; Cole, KJ; Tang, D; Rauh, V; Phillips, DH
HERO ID
1455483
Reference Type
Journal Article
Year
2011
Language
English
PMID
| HERO ID | 1455483 |
|---|---|
| In Press | No |
| Year | 2011 |
| Title | Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children |
| Authors | Perera, FP; Wang, S; Vishnevetsky, J; Zhang, B; Cole, KJ; Tang, D; Rauh, V; Phillips, DH |
| Journal | Environmental Health Perspectives |
| Volume | 119 |
| Issue | 8 |
| Page Numbers | 1176-1181 |
| Abstract | <strong>BACKGROUND: </strong>Airborne polycyclic aromatic hydrocarbons (PAH) are widespread urban pollutants that can bind to DNA to form PAH-DNA adducts. Prenatal PAH exposure measured by personal monitoring has been linked to cognitive deficits in childhood in a prospective study conducted by the Columbia Center for Children's Environmental Health.<br /><br /><strong>OBJECTIVES: </strong>We measured PAH-DNA and other bulky aromatic adducts in umbilical cord white blood cells using the 32P-postlabeling assay to determine the association between this molecular dosimeter and behavioral/attention problems in childhood.<br /><br /><strong>METHODS: </strong>Children born to nonsmoking African-American and Dominican women residing in New York City (NYC) were followed from in utero to 7-8 years of age. At two time points before 8 years of age (mean ages, 4.8 years and 7 years), child behavior was assessed using the Child Behavior Checklist (CBCL). To estimate and test the association between adducts and behavioral outcomes, both CBCL continuous raw scores and dichotomized T-scores were analyzed.<br /><br /><strong>RESULTS: </strong>Higher cord adducts were associated with higher symptom scores of Anxious/Depressed at 4.8 years and Attention Problems at 4.8 and 7 years, and with Diagnostic and Statistical Manual of Mental Disorders, 4th edition-oriented Anxiety Problems at 4.8 years.<br /><br /><strong>CONCLUSIONS: </strong>These results suggest that PAH exposure, measured by DNA adducts, may adversely affect child behavior, potentially affecting school performance. |
| Doi | 10.1289/ehp.1002705 |
| Pmid | 21486719 |
| Wosid | WOS:000293444300038 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | cord blood; DNA adducts; neurodevelopment; PAH; P-32-postlabeling |