Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality
Gan, WQ; Fitzgerald, JM; Carlsten, C; Sadatsafavi, M; Brauer, M
HERO ID
1464686
Reference Type
Journal Article
Year
2013
Language
English
PMID
| HERO ID | 1464686 |
|---|---|
| In Press | No |
| Year | 2013 |
| Title | Associations of ambient air pollution with chronic obstructive pulmonary disease hospitalization and mortality |
| Authors | Gan, WQ; Fitzgerald, JM; Carlsten, C; Sadatsafavi, M; Brauer, M |
| Journal | American Journal of Respiratory and Critical Care Medicine |
| Volume | 187 |
| Issue | 7 |
| Page Numbers | 721-727 |
| Abstract | Rationale: Ambient air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD). However, there is a lack of longitudinal studies to support this assertion. Objectives: To investigate the associations of long-term exposure to elevated traffic-related air pollution and woodsmoke pollution with the risk of COPD hospitalization and mortality. Methods: This population-based cohort study included a 5-year exposure period and a 4-year follow-up period. All residents aged 45-85 years who resided in Metropolitan Vancouver, Canada, during the exposure period and did not have known COPD at baseline were included in this study (N = 467,994). Residential exposures to traffic-related air pollutants (black carbon, particulate matter < 2.5 µm in aerodynamic diameter, nitrogen dioxide, and nitric oxide) and woodsmoke were estimated using land-use regression models and integrating changes in residences during the exposure period. COPD hospitalizations and deaths during the follow-up period were identified from provincial hospitalization and death registration databases. Measurements and Main Results: An interquartile range elevation in black carbon concentrations (0.97×10-5/m, equivalent to 0.78 µg/m3 elemental carbon) was associated with a 6% (95% confidence interval, 2-10%) increase in COPD hospitalizations and a 7% (0-13%) increase in COPD mortality after adjustment for covariates. Exposure to higher levels of woodsmoke pollution (tertile 3 versus tertile 1) was associated with a 15% (2-29%) increase in COPD hospitalizations. There were positive exposure-response trends for these observed associations. Conclusions: Ambient air pollution, including traffic-related fine particulate pollution and woodsmoke pollution, is associated with an increased risk of COPD. |
| Doi | 10.1164/rccm.201211-2004OC |
| Pmid | 23392442 |
| Wosid | WOS:000317316200013 |
| Url | http://ajrccm.atsjournals.org/cgi/doi/10.1164/rccm.201211-2004OC |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000317316200013 |
| Is Public | Yes |
| Language Text | English |
| Keyword | particulate matter; soot; woodsmoke; cohort studies |