Mutagenic Activities of Selected Nitrofluoranthene Derivatives in Salmonella typhimurium Strains TA98, TA98NR and TA98/1,8-DNP6
Zielinska, B; Arey, J; Harger, WP; Lee, RWK
| HERO ID | 1482652 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | Mutagenic Activities of Selected Nitrofluoranthene Derivatives in Salmonella typhimurium Strains TA98, TA98NR and TA98/1,8-DNP6 |
| Authors | Zielinska, B; Arey, J; Harger, WP; Lee, RWK |
| Journal | Mutation Research |
| Volume | 206 |
| Issue | 2 |
| Page Numbers | 131-140 |
| Abstract | The mutagenic activities of novel nitrofluoranthene derivatives were studied in-vitro. The compounds were synthesized by reacting fluoranthene (206440), 2-nitrofluoranthene (13177292), or 3-nitrofluoranthene (892217) with nitrogen-dioxide in carbon-tetrachloride at room temperature. Thirteen compounds were tested for mutagenicity in the Amesalmonella assay using strains (TA-98), (TA-98NR), and (TA-98/1,8DNP6) in the presence or absence of S9 mix from aroclor-1254 induced rat liver. All nitrofluoranthene derivatives were mutagenic in (TA-98) in the absence of S9 mix. All but one of the compounds were less mutagenic in (TA-98NR), compared with (TA-98). In (TA-98/1,8DNP6) all but two compounds showed sharply reduced mutagenic activity, at least 50 percent, relative to (TA-98). When S9 mix was present, most compounds showed significantly reduced mutagenic activity. The authors conclude that adding a second or third nitro group to the naphthalene moiety of the fluoranthene molecule does not significantly increases its mutagenicity in strain (TA-98) over that of mono nitrofluoranthenes. |
| Doi | 10.1016/0165-1218(88)90152-8 |
| Pmid | 3050495 |
| Wosid | WOS:A1988Q606900001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: MUTAT RES 206 ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>DCN-172949</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Nitro compounds</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Molecular structure</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Mutagenesis</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>In vitro studies</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Microbial test systems</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Bioassays</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Fluorinated hydrocarbons</kw> |