N-nitroso compounds produced in deer mice (Peromyscus maniculatus) exposed to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
Pan, X; Zhang, B; Smith, JN; San Francisco, M; Anderson, TA; Cobb, GP
| HERO ID | 1508477 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 2006 |
| Title | N-nitroso compounds produced in deer mice (Peromyscus maniculatus) exposed to hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) |
| Authors | Pan, X; Zhang, B; Smith, JN; San Francisco, M; Anderson, TA; Cobb, GP |
| Journal | Chemosphere |
| Volume | 232 |
| Page Numbers | 520 |
| Abstract | Given the potent carcinogenic effects of most N-nitroso compds., the reductive transformation of the common explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to a group of N-nitroso derivs., hexahydro-1-nitroso-3,5-dinitro-1,3,5-triazine (MNX), hexahydro-1,3-dinitroso-5-nitro-1,3,5-triazine (DNX) and hexahydro-1,3,5-trinitroso-1,3,5-triazine (TNX) in the environment have caused concerns among the general public. Questions are arising about whether the same transformations also occur in mammals and, if true, to what extent. This study investigated the N-nitroso derivs. prodn. in the deer mice GI tract following RDX administration. The findings verified that such transformations do occur in the mammalian GI tract at notable levels: the av. MNX concns. in deer mice stomach were 85 ng/g and 1,318 ng/g for exposure to 10 mg/kg and 100 mg/kg diet, resp. DNX in stomach were 217 and 498 ng/g for 10 mg/kg and 100 mg/kg dietary exposure, resp. Changes in other toxic endpoints including body wt. gains, food consumptions, organ wts. and behaviors were also reported. |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | San Francisco, CA, USA |
| Conference Name | 232nd National Meeting of the American-Chemical-Society |
| Conference Date | September 10 -14, 2006 |
| Is Public | Yes |
| Language Text | English |