Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells
Zedda, G; Simbula, G; Begala, M; Pibiri, M; Floris, C; Casu, M; Casu, L; Tocco, G
| HERO ID | 1514131 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | Mild synthetic approach to novel indole-1-carbinols and preliminary evaluation of their cytotoxicity in hepatocarcinoma cells |
| Authors | Zedda, G; Simbula, G; Begala, M; Pibiri, M; Floris, C; Casu, M; Casu, L; Tocco, G |
| Journal | Archiv der Pharmazie |
| Volume | 345 |
| Issue | 3 |
| Page Numbers | 195-202 |
| Abstract | A mild and versatile method for the synthesis of some novel indole-1-carbinols has been developed via one-pot reaction of indoles and paraformaldehyde in the presence of an excess of CaO, MgO, ZnO or TiO(2). The solvent-free reaction provided all the indole derivatives in moderate to good yields and short reaction times. Moreover, the effect of some selected indole-1-carbinols on cell proliferation of the hepatoma cell line FaO was evaluated. |
| Doi | 10.1002/ardp.201100104 |
| Pmid | 22715502 |
| Wosid | WOS:000301046900004 |
| Url | /www.wiley-vch.de |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Toxicology; Pharmacology & Pharmacy; Apoptosis, Cytotoxicity, Hepatocarcinoma, Indole-1-carbinols,; Solvent-free reaction; poly(adp-ribose) polymerase, indole-3-carbinol, cleavage, pyrrole, agent |