Lack Of Nephrotoxicity Of Dimethyl Sulfoxide In Man And Laboratory Animals AU - Bennett WM
Bristol, T; Weaver, WJ; Muther, RS
| HERO ID | 1514318 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Lack Of Nephrotoxicity Of Dimethyl Sulfoxide In Man And Laboratory Animals AU - Bennett WM |
| Authors | Bristol, T; Weaver, WJ; Muther, RS |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 411 |
| Page Numbers | 43-47 |
| Abstract | Nephrotoxic effects of dimethyl-sulfoxide (67685) (DMSO) were studied in humans and laboratory animals. Twenty one patients (17 males) and chronic stable neurologic deficits related to traumatic spinal cord injury were infused intravenously (iv) with 1 gram per kilogram (g/kg) DMSO for 10 minutes to 24 hours. Some patients were infused for 3 days. Parameters of kidney function such as blood urea nitrogen (BUN), serum creatinine, creatinine clearance, hemoglobin, myoglobin, urinary protein, glucose, and specific gravity were determined. No changes from baseline in BUN, serum, creatinine, and creatinine clearance were seen. Some hemoglobinuria was observed; no myoglobin was present. No increase in qualitative urine protein or glucose, nor decrease in first morning specific gravity was observed. Male Fischer-rats were given 40 percent DMSO iv for 15 minutes for 3 days. The animals were killed 72 hours later. Serum creatinine was determined and the kidneys were examined for histopathological changes. Acute renal failure was induced in rats by injecting 5 to 20 milligrams per kilogram potassium-dichromate. The animals were given 0 or 1g/kg DMSO intraperitoneally. They were killed 1 to 5 days later and serum creatinine was determined. In rats given DMSO iv over 3 days, no renal histopathological changes were seen. No significant changes in serum creatinine concentration occurred. No evidence of added nephrotoxicity, as indicated by changes in serum creatinine, was noted in rats with dichromate induced kidney failure given DMSO, compared with those given potassium-dichromate alone. The authors conclude that DMSO causes no short term nephrotoxic effect. DMSO given iv is safe to use in patients who are prospective renal transplant donors. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | DCN-146594; Laboratory animals; Laboratory techniques; Biological factors; Analytical methods; Protein chemistry; Liver function; Toxic effects; Chemical composition; Urinalysis; Kidney function; Hepatotoxicity; 67-68-5 |