Mutagenicity of Complex Mixtures Used in Tannery
Bronzetti, G; Vellosi, R; Galli, A; Nieri, R; Corsi, C; Cundari, E; Paolini, M; Del Carratore, R
| HERO ID | 1514320 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Mutagenicity of Complex Mixtures Used in Tannery |
| Authors | Bronzetti, G; Vellosi, R; Galli, A; Nieri, R; Corsi, C; Cundari, E; Paolini, M; Del Carratore, R |
| Journal | Toxicological and Environmental Chemistry |
| Volume | 13 |
| Page Numbers | 1-2 |
| Abstract | A group of twenty eight commercial compounds used in a leather and tannery factory (SIC-3111) near Florence, Italy, were tested for mutagenic response following the procedures described by Ames. The S9 fraction of livers from mice pretreated with phenobarbital and beta-naphthoflavone was used as an activating system. The chemical composition was available for about five products, others were listed by commercial names. Eight products gave positive responses in one or more strains of Salmonella-typhimurium, and five responded positively in Saccharomyces-cervisiae (D7). Tanning agents Chromitan-B (CB) and Chromitan-MS (CMS) contained chromium(III) (16065831), but no chromium(VI) (18540299) was detected. CB was toxic to Salmonella (TA-98) and (TA-1537), and CMS was toxic to (TA-1537). Bruno-Avival (BA) and Rosso-Avival (RA) dyes were mutagenic to (TA-98) and (TA-1537), and Rosso-HR (RHR) induced histidine revertants in (TA-100) and (TA-98). CB, CMS, BA, RA, and RHR induced gene conversion and point mutation in (D7) of Saccharomyces. Silican and Blancotan-PRV showed weak genetic effects, but neither contained chromium(III). Erhavit-A, a product used in the liming process, gave positive results using (TA-1535), with or without metabolic activation. None of the two disinfectants and nine oil resins induced mutagenic response in Salmonella strains or (D7). The authors conclude that these results suggest that environmental health risks should be studied with complex mixtures as they occur in the environment. |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | DCN-153588; Tanning industry; Leather industry; Leather workers; Chromium compounds; Industrial exposures; Mutagenicity; Health hazards; Worker health; 16065-83-1; 18540-29-9 |