Practical guidance for evaluating and interpreting developmental toxicity tests
Harris, SB; DeSesso, JM
| HERO ID | 1580417 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | Practical guidance for evaluating and interpreting developmental toxicity tests |
| Authors | Harris, SB; DeSesso, JM |
| Journal | Journal of Hazardous Materials |
| Volume | 39 |
| Issue | 2 |
| Page Numbers | 245-266 |
| Abstract | The complex physiological interactions among a pregnant mammal, her embryos, and their placentae pose considerable challenges to investigators who conduct safety tests for the assessment of potential developmental toxicity. Many individuals who review developmental toxicity safety tests are not trained in this specialized area of toxicology. This paper presents a concise introduction to the science that underlies developmental toxicology for those individuals. The purpose of the paper is to educate the reader about appropriate test procedures, the types of data that are collected, and evaluation of studies. To these ends, the paper explains important terminology and study designs; makes comments concerning what should be considered acceptable developmental toxicity data; and provides insights and rules of thumb regarding the evaluation and interpretation of the data. |
| Doi | 10.1016/0304-3894(94)00052-2 |
| Wosid | WOS:A1994PP99200010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:A1994PP99200010 |
| Is Public | Yes |