Influence of propolis water solution on heart mitochondrial function
Majiene, D; Trumbeckaite, S; Savickas, A; Toleikis, A
| HERO ID | 1596884 |
|---|---|
| In Press | No |
| Year | 2006 |
| Title | Influence of propolis water solution on heart mitochondrial function |
| Authors | Majiene, D; Trumbeckaite, S; Savickas, A; Toleikis, A |
| Journal | Journal of Pharmacy and Pharmacology |
| Volume | 58 |
| Issue | 5 |
| Page Numbers | 709-713 |
| Abstract | The effect of propolis water solution (PWS) on the respiration of rat heart mitochondria with NAD-linked (pyruvate + malate), FAD-linked (succinate) substrates and fatty acids (palmitoyl-(L)-carnitine) was investigated in this study. PWS at the lowest concentration of 4 mu g mL(-1) of phenolic compounds (PC) had no effect on mitochondrial respiration with all investigated substrates. PWS at concentrations of 63 and 125 mu g mL(-1) of PC caused a significant decrease of basal (24 and 54 %) and maximal (58 and 70 %) respiration rates with succinate as substrate. At these PWS concentrations the oxidation of pyruvate+malate and palmitoyl-(L)-carnitine was diminished to a lower degree: the basal respiration rate decreased by 13-18 % and the maximal respiration rate by 15-28 %. Succinate oxidation was affected, probably because of the inhibition of succinate dehydrogenase by the 1,2- benzenedicarboxylic acid esters found in PWS. The PWS-caused decrease in the mitochondrial respiration rate with pyruvate+malate and fatty acids could be due to diminished activities of respiratory chain complexes and/or ADP/ATP translocator. |
| Doi | 10.1211/jpp.58.5.0017 |
| Pmid | 16640841 |
| Wosid | WOS:000237768500017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000237768500017 |
| Is Public | Yes |