Letter from ConocoPhillips to U.S. EPA regarding: Naphthalene (CAS#: 91-20-3) preliminary findings of an acute inhalation study in rats
HERO ID
1597220
Reference Type
Technical Report
Subtype
TSCA Submission
Year
2007
Language
English
| HERO ID | 1597220 |
|---|---|
| Material Type | TSCA Submission |
| Year | 2007 |
| Title | Letter from ConocoPhillips to U.S. EPA regarding: Naphthalene (CAS#: 91-20-3) preliminary findings of an acute inhalation study in rats |
| Authoring Organization | ConocoPhillips Company |
| Publisher Text | U.S. Environmental Protection Agency |
| City | Washington, DC |
| Abstract | ConocoPhillips Company is involved with an industry group that has sponsored an acute inhalation study in rats involving naphthalene. As a sponsor, ConocoPhillips has been provided with a preliminary draft of the pathology report. ConocoPhillips is submitting this draft study report in accordance with Section 8(e) of the Toxic Substances Control Act (TSCA) because it includes findings that EPA may consider reportable. Toxicological endpoints observed in this study are not new; however, the naphthalene concentrations and duration of exposure in this study may be considered a new finding. ConocoPhillips is submitting a preliminary rough draft of data on the acute effects of naphthalene vapors on nasal epithelial cells in rats. Two strains of rats, Fischer 344 (F344) and Sprague Dawley, were exposed to naphthalene vapors at the following target concentrations: 0, 0.1, 0.3, 1, 10 and 30 ppm for a single six hour period. A total of 30 animals of each sex per strain were exposed. The day following exposure, the animals were killed and nasal respiratory tissues were removed, processed with hematoxylin and eosin stains, and subsequently evaluated by light microscopy. Necrosis related to exposure to naphthalene was seen predominately in the olfactory epithelium. According to the preliminary pathology report, minimal effects were first observed in all groups exposed to a naphthalene vapor concentration of 1 ppm. Clear and strong pathological changes were observed in all groups exposed to vapor concentrations of 10 ppm and 30 ppm. |
| Report Number | 8EHQ-0807-16921A; 88070000339 |
| Ntis Number | 88070000339 |
| Tscats Number | 091203 |
| Url | http://www.epa.gov/oppt/tsca8e/pubs/8ehq/2007/aug07/8ehq_0807_16921a.pdf |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |