Risk factors for sensitisation to methyltetrahydrophthalic anhydride
Yokota, K; Johyama, Y; Yamaguchi, K; Fujiki, Y; Takeshita, T; Morimoto, K
HERO ID
1599090
Reference Type
Journal Article
Year
1997
Language
English
PMID
| HERO ID | 1599090 |
|---|---|
| In Press | No |
| Year | 1997 |
| Title | Risk factors for sensitisation to methyltetrahydrophthalic anhydride |
| Authors | Yokota, K; Johyama, Y; Yamaguchi, K; Fujiki, Y; Takeshita, T; Morimoto, K |
| Journal | Occupational and Environmental Medicine |
| Volume | 54 |
| Issue | 9 |
| Page Numbers | 667-670 |
| Abstract | <strong>OBJECTIVES: </strong>To examine an association between specific IgE to methyltetrahydrophthalic anhydride (MTHPA) and exposure time, atopic history, smoking habits, and total IgE concentrations.<br /><br /><strong>METHODS: </strong>A cross sectional survey was carried out on a population of 148 workers from two condenser plants using epoxy resin with MTHPA, an acid anhydride curing agent known to cause allergy.<br /><br /><strong>RESULTS: </strong>Using a Pharmacia CAP system with a MTHPA human serum albumin conjugate, specific IgE antibody was detected in serum from 97 (66%) out of the 148 workers exposed to MTHPA. Stepwise multiple linear regression analysis showed a striking relation between log concentrations of specific and total IgE (P < 0.0001). Furthermore, when the workers were divided into two groups according to a cut-off point (100 IU/ml) between low and high total IgE, current smoking was significantly (P = 0.025) associated with specific IgE production only in the group with low total IgE (< 100 IU/ml).<br /><br /><strong>CONCLUSIONS: </strong>Smoking is the most significant risk factor for raising specific IgE to MTHPA in the group with low total IgE concentrations. |
| Doi | 10.1136/oem.54.9.667 |
| Pmid | 9423580 |
| Wosid | WOS:A1997XU79100008 |
| Is Certified Translation | No |
| Dupe Override | 1599090 |
| Is Public | Yes |
| Language Text | English |