Evaluation of N-isopropyl-[125I]p-iodoamphetamine affinity sites in rat brain by autoradiography
Kondoh, Y; Murakami, M; Takahashi, K; Itoh, I; Mizusawa, S; Nakamichi, H; Sasaki, H; Watanabe, K; Tagawa, K; Uemura, K
| HERO ID | 1617038 |
|---|---|
| In Press | No |
| Year | 1986 |
| Title | Evaluation of N-isopropyl-[125I]p-iodoamphetamine affinity sites in rat brain by autoradiography |
| Authors | Kondoh, Y; Murakami, M; Takahashi, K; Itoh, I; Mizusawa, S; Nakamichi, H; Sasaki, H; Watanabe, K; Tagawa, K; Uemura, K |
| Journal | Tohoku Journal of Experimental Medicine |
| Volume | 149 |
| Issue | 2 |
| Page Numbers | 229-230 |
| Abstract | Affinity sites of N-isopropyl-[125I]p-iodoamphetamine (IMP) were studied in rat brain employing in vitro technique of receptor autoradiography. High degrees of IMP accumulation were observed in almost regions of white matter and some of gray matter. Phenethylamine, glutamic acid and serotonin suppressed IMP accumulation in all brain regions, in cerebral cortex and in hypothalamus, respectively. These results indicated that IMP was accumulated mainly due to its physicochemical property of lipophilicity and might have some interactions with neurotransmitter receptors. |
| Pmid | 2875546 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |