The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones
Ansell, JM; Fowler, JA
| HERO ID | 1618119 |
|---|---|
| In Press | No |
| Year | 1988 |
| Title | The acute oral toxicity and primary ocular and dermal irritation of selected N-alkyl-2-pyrrolidones |
| Authors | Ansell, JM; Fowler, JA |
| Journal | Food and Chemical Toxicology |
| Volume | 26 |
| Issue | 5 |
| Page Numbers | 475-479 |
| Abstract | N-alkyl-2-pyrrolidones are a class of materials that are increasingly used in food, drug, cosmetic and industrial applications; however, toxicological data is only available for a few members of the class. The acute oral toxicity, primary dermal irritation and primary ocular irritation of N-methyl-, N-ethyl-, N-hydroxyethyl-, N-isopropyl-, N-cyclohexyl-, N-octyl-, N-dodecyl-, N-coco- and N-tallow-2-pyrrolidone are reported. Additionally, N-octyl-, N-decyl-, N-dodecyl-, N-tetradecyl-, N-hexadecyl- and N-octadecyl-2-pyrrolidone had the primary ocular and dermal irritation indices measured as a 2% aqueous suspension. These data show a wide range of toxicities dependent upon the alkyl substituent. |
| Doi | 10.1016/0278-6915(88)90060-9 |
| Pmid | 3391472 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | BIOCHEMISTRY; FOOD-PROCESSING INDUSTRY; FOOD TECHNOLOGY; SKIN DISEASES/PATHOLOGY; SENSE ORGANS/PATHOLOGY; PHARMACOLOGY; POISONING; ANIMALS, LABORATORY; LAGOMORPHA; MURIDAE; Biochemical Studies-General; Food Technology-Preparation; Integumentary System-Pathology; Sense Organs; Pharmacology-General; Toxicology-General; Leporidae; 59005-08-2; 59005-06-0; 55257-88-0; 7425-87-8; 6837-24-7; 3772-26-7; 3445-11-2; 2687-96-9; 2687-94-7; 2687-91-4; 872-50-4; 88-12-0 |