Effect of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors
Ogiso, T; Iwaki, M; Paku, T
| HERO ID | 1620210 |
|---|---|
| In Press | No |
| Year | 1995 |
| Title | Effect of various enhancers on transdermal penetration of indomethacin and urea, and relationship between penetration parameters and enhancement factors |
| Authors | Ogiso, T; Iwaki, M; Paku, T |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | Pharm |
| Issue | REF 39 |
| Page Numbers | 482-488 |
| Abstract | IPA COPYRIGHT: ASHP To investigate the effects of various penetration enhancers on indomethacin (IND) and urea permeation, in vitro permeation experiments with hairless rat skin were conducted. Laurocapram, isopropyl myristate (IPM), sodium oleate, and eucalyptol (cineol) increased fluxes of both agents to a great extent. Many enhancers increased lipid fluidity, skin partitioning of IND, extraction of ceramides from cornified cells, and thermodynamic activity of IND to varying extents. A good correlation was observed between increase in stratum corneum lipid fluidity and partitioning of IND into skin, between increase in fluidity and flux or decrease in lag time for IND, between removal of ceramides and skin partitioning of IND, and between removal of ceramides and flux of urea. The order of enhancement potency tested with IND was laurocapram>oleic acid>glyceryl monooleate (monoolein)>sodium oleate>eucalyptol and IPM, and the order with urea was octyl alcohol (n-octanol)>eucalyptol>laurocapram=glyceryl monooleate=oleic acid>sodium oleate>(+)-limonene (d-limonen)>IPM. |
| Doi | 10.1002/jps.2600840418 |
| Pmid | 7629741 |
| Wosid | WOS:A1995QR36600017 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Authoring Organization: EASTMAN KODAK CO |
| Is Public | Yes |
| Language Text | English |
| Keyword | <?xml version="1.0" encoding="UTF-8"?><kw>Indomethacin</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>permeation</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>absorption enhancers</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Urea</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Laurocapram</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>effects</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>indomethacin</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Isopropyl myristate</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Sodium oleate</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Oleic acid</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Eucalyptol</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Glyceryl monooleate</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Alcohols</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>(+)-Limonene</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Anti-inflammatory agents</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>indomethacin(Anti-inflammatory agents</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Diuretics</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>urea(Diuretics</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Cineol</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>Monoolein</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>n-Octanol</kw>; <?xml version="1.0" encoding="UTF-8"?><kw>d-Limonene</kw> |