Plasma nitrite/nitrate and erythropoietin levels in cross-country skiers during altitude training
Schena, F; Cuzzolin, L; Rossi, L; Pasetto, M; Benoni, G
| HERO ID | 1656011 |
|---|---|
| In Press | No |
| Year | 2002 |
| Title | Plasma nitrite/nitrate and erythropoietin levels in cross-country skiers during altitude training |
| Authors | Schena, F; Cuzzolin, L; Rossi, L; Pasetto, M; Benoni, G |
| Journal | Journal of Sports Medicine and Physical Fitness |
| Volume | 42 |
| Issue | 2 |
| Page Numbers | 129-134 |
| Abstract | <strong>BACKGROUND: </strong>The aim of this study was to evaluate the effects of training at altitude on plasma nitrite/nitrate and erythropoietin levels since previously it has been reported an interaction of the NO/cGMP system in erythropoietin production.<br /><br /><strong>METHODS: </strong>Nine physically trained cross-country male skiers, usually living at 800-1200 m altitude, underwent 6 days of intensive training at a moderate altitude of 3100 m preceeded by 2 days of acclimatisation. Six team-managers, selected as controls, did not undergo any regular physical activity in the last 5 years and during the altitude period. Haematological parameters, erythropoietin and nitrite/nitrate were measured prior to reach the place at altitude, at the end of the period at moderate altitude and 7 days after returning at home.<br /><br /><strong>RESULTS: </strong>Haematocrit significantly increased in controls after 8 days at altitude. Erythropoietin levels significantly increased after the intensive altitude training only in trained subjects (13.1+/-1.7 vs 6.7+/-1.7 mU x ml-1, p<0.001). Nitrite/nitrate baseline values were significantly higher in trained subjects compared to untrained (49.9+/-17.9 vs 25.4+/-2.8 micromol x l(-1), p<0.01); the altitude period significantly increased nitrite/nitrate levels, in untrained subjects, to the same values observed in trained subjects under control conditions (47.0+/-10.3 micromol x l(-1)).<br /><br /><strong>CONCLUSIONS: </strong>In our experimental conditions we demonstrated the influence of hypoxia on Epo levels in athletes sustaining a short-term training and the role of a regular physical activity (partly independent from altitude hypoxia) on NO production. |
| Pmid | 12032406 |
| Wosid | WOS:000176950800001 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000176950800001 |
| Is Public | Yes |
| Language Text | English |
| Keyword | nitric oxide; erythropoiesis; anoxia; exercise |