Interactive mutagenicity of sodium nitrite, dimethylamine, methylurea and ethylurea
Couch, DB; Friedman, MA
HERO ID
17502
Reference Type
Journal Article
Year
1975
Language
Dutch
PMID
| HERO ID | 17502 |
|---|---|
| In Press | No |
| Year | 1975 |
| Title | Interactive mutagenicity of sodium nitrite, dimethylamine, methylurea and ethylurea |
| Authors | Couch, DB; Friedman, MA |
| Journal | DNA Repair |
| Volume | 31 |
| Issue | 2 |
| Page Numbers | 109-114 |
| Abstract | Groups of mice were treated per os with sodium nitrite either alone or in combination with nitrosatable amino compounds and tested in the host mediated assay. When mice were treated with sodium nitrite in combination with dimethylamine a small(4-fold) but significant increase in mutant frequency (MF) was observed. Ethylurea or methylurea in combination with sodium nitrite induced 10- or 850-fold increases in MF, respectively. The response to methylurea was dose-dependent with a 6- and 30-fold increase in MF at 5.4 and 11.5 mg/kg NaNO2 and a 6-fold increase at 108 mg/kg methylurea. That this response reflected gastric nitrosation was shown by the disappearance of the response if NaNO2 administration preceded methylurea treatment by 10 min. High MF's were observed if NaNO2 was administered 10 or 20 min after methylurea. |
| Doi | 10.1016/0165-1161(75)90073-4 |
| Pmid | 1090815 |
| Wosid | WOS:A1975V878400005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | Dutch |