Inhibition of irritation and contact hypersensitivity by ethacrynic acid
Wille, JJ; Kydonieus, AF; Kalish, RS
| HERO ID | 1802921 |
|---|---|
| In Press | No |
| Year | 1998 |
| Title | Inhibition of irritation and contact hypersensitivity by ethacrynic acid |
| Authors | Wille, JJ; Kydonieus, AF; Kalish, RS |
| Journal | Skin Pharmacology and Applied Skin Physiology |
| Volume | 11 |
| Issue | 4-5 |
| Page Numbers | 279-288 |
| Abstract | The immunosuppressive effect of topical ethacrynic acid (ECA) was tested on both the induction and elicitation phases of contact sensitization in a mouse model. ECA (0.5% in vehicle) reduced the sensitization response by >50% when the sensitizer was either dinitrochlorobenzene (DNCB), oxazalone (OX) or para-phenylenediamine (PPD), and was applied 1 day later to the ECA-pretreated skin site. The immunosuppressive effect of combining ECA with either hydrocortisone or with cis-urocanic acid was also tested. An additive suppressive effect was observed with ECA in both combinations. The effect of ECA (1% in vehicle) on blocking the elicitation phase was also examined in a mouse ear edema assay. ECA was highly effective in preventing the challenge response in mice previously sensitized to either DNCB, OX or PPD. ECA (1% in vehicle) was also tested for its ability to inhibit contact irritation. ECA (1% in vehicle) was highly effective in preventing ear edema due to topically applied skin irritants including arachidonic acid, capsaicin, lactic acid, phorbol myristate acetate, trans-retinoic acid, and sodium lauryl sulfate. ECA may be useful for both prophylaxis and therapeutic treatment of diverse skin conditions including contact dermatitis, eczema, and other related allergic skin disorders. |
| Doi | 10.1159/000029838 |
| Pmid | 9885413 |
| Wosid | WOS:000078281600012 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Source: Web of Science WOS:000078281600012Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032457850&doi=10.1159%2f000029838&partnerID=40&md5=441d8e467a3f1a3fb62f55370017c510 |
| Is Public | Yes |
| Language Text | English |
| Keyword | allergic contact dermatitis; ethacrynic acid; skin irritation; skin sensitization |