Morphological recovery of the granule cells from the olfactory bulb after the cessation of acute ozone exposure
Colín-Barenque, L; Dorado-Martinez, C; Rivas-Arancibia, S; Avila-Costa, MR; Fortoul, TI
HERO ID
180458
Reference Type
Journal Article
Year
2005
Language
English
PMID
| HERO ID | 180458 |
|---|---|
| In Press | No |
| Year | 2005 |
| Title | Morphological recovery of the granule cells from the olfactory bulb after the cessation of acute ozone exposure |
| Authors | Colín-Barenque, L; Dorado-Martinez, C; Rivas-Arancibia, S; Avila-Costa, MR; Fortoul, TI |
| Journal | International Journal of Neuroscience |
| Volume | 115 |
| Issue | 3 |
| Page Numbers | 411-421 |
| Abstract | The purpose of this study was to analy/e lhe possible morphological reL-overy of lhe granule cells in the olfactory bulb as a consequence of oxidative stress after an acute ozone exposure. Rats were divided in two groups: Control (air exposed) and experimental group, exposed 4 h. to I ppni ozone and divided into 4 subgroups, which were sacrificed al 2 and 24 h. 10 and 15 days, respectively. Olfactory bulbs were processed with the rapid Golgi method and for transmission electron microscopy. The granule cells of the olfactory bulb disclosed less dendritic spine density at 2. 24 h. and If) days after the exposure compared with conirols. At 15 days, the number of spines increased to values similar to those found in controls. The granule cells ultrastructure demonstrated an increment in lipofucsin granules, as well as swollen orgunelles, changes that decreased overtime. This change decline might be related to a partial recovery of the asst.K.-iative granule cells funciion. |
| Doi | 10.1080/00207450590521028 |
| Pmid | 15804724 |
| Wosid | WOS:000227143600010 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | dendritic spines; granule ceils; olfactory bulb; oxidative stress; ozone; recovery; ultrastructure |
| Is Qa | No |