Evaluation of potential modes of action of inhaled ethylbenzene in rats and mice
Stott, WT; Johnson, KA; Bahnemann, R; Day, SJ; Mcguirk, RJ
HERO ID
184338
Reference Type
Journal Article
Year
2003
Language
English
PMID
| HERO ID | 184338 |
|---|---|
| In Press | No |
| Year | 2003 |
| Title | Evaluation of potential modes of action of inhaled ethylbenzene in rats and mice |
| Authors | Stott, WT; Johnson, KA; Bahnemann, R; Day, SJ; Mcguirk, RJ |
| Journal | Toxicological Sciences |
| Volume | 71 |
| Issue | 1 |
| Page Numbers | 53-66 |
| Abstract | Potential factors underlying the tumorigenic activity of ethylbenzene (EB) were examined in F344 rats and B6C3F1 mice inhaling 750 ppm EB vapor 6 h/day, 5 days/week, for one or four weeks. Target tissues (kidneys of rats and livers and lungs of mice) were evaluated for changes in organ weights, mixed function oxygenases (MFO), glucuronosyl transferase activities, S-phase DNA synthesis, apoptosis, alpha2u-globulin deposition, and histopathology. In male rats, kidney weight increases were accompanied by focal increases in hyaline droplets, alpha2u-globulin, degeneration, and S-phase synthesis in proximal tubules. In female rats, only decreased S-phase synthesis and MFO activities occurred. In mice, increased liver weights were accompanied by hepatocellular hypertrophy, mitotic figures, S-phase synthesis, and enzyme activities. S-phase synthesis rates in terminal bronchiolar epithelium were elevated and accompanied by loss of MFO activity. Exposure to a nontumorigenic level of 75 ppm for one week caused few changes. These data, considered with the general lack of EB genotoxicity, suggest a mode of tumorigenesis dependent upon increased cell proliferation and altered population dynamics in male rat kidney and mouse liver and lungs. A similar response in the kidneys of female rats appears to require a longer exposure period than was employed. |
| Doi | 10.1093/toxsci/71.1.53 |
| Pmid | 12520075 |
| Wosid | WOS:000180363000007 |
| Url | https://www.proquest.com/docview/72961978?accountid=171501&bdid=65280&_bd=Z%2FH8bz7NntD1F1A64gHYFrXxH8w%3D |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | ethylbenzene; inhalation exposure; tumorigenesis; mode of action; target tissues; S-phase DNA |
| Relationship(s) |