Kinetic and mechanistic data needs for a human phsiologically based pharmacokinetic (PBPK) model for acrylamide
Andersen, ME; Scimeca, J; Olin, SS
HERO ID
19012
Reference Type
Journal Article
Subtype
Review
Year
2005
Language
English
PMID
| HERO ID | 19012 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2005 |
| Title | Kinetic and mechanistic data needs for a human phsiologically based pharmacokinetic (PBPK) model for acrylamide |
| Authors | Andersen, ME; Scimeca, J; Olin, SS |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 561 |
| Issue | 6 |
| Page Numbers | 117-125 |
| Abstract | A pharmacokinetic (PBPK) model has been developed for acrylamide (AMD) and its oxidative metabolite, glycidamide (GLY), in the rat based on available information. Despite gaps and limitations to the database, model parameters have been estimated to provide a relatively consistent description of the kinetics of acrylamide and glycidamide using a single set of values (with minor adjustments in some cases). Future kinetic and mechanistic studies will need to focus on the collection of key data for refining certain model parameters and for model validation, as well as for conducting studies that elucidate the mechanism of action. Development of a validated human AMD/GLY PBPK model capable of predicting target tissue doses at relevant dietary AMD exposures, in combination with expanding data on modes of action, should allow for a substantive improvement in the risk assessment of acrylamide in food. |
| Doi | 10.1021/tx050337k |
| Pmid | 16780359 |
| Wosid | WOS:000238323200011 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Name | 1st International Symposium on Chemistry and Safety of Acrylamide in Food |
| Conference Date | MAR 29-31, 2004 |
| Comments | ECRIB.Chem. Biol. Interact. 135: 267-284. |
| Is Public | Yes |
| Language Text | English |
| Keyword | 2-Chloro-1,3-butadiene; (1-Chloroethenyl)oxirane; Metabolism; Species differences |
| Is Qa | No |
| Relationship(s) |
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