A new protocol and criteria for quantitative determination of sensitization potencies of chemicals by guinea pig maximization test
Nakamura, A; Momma, J; Sekiguchi, H; Noda, T; Yamano, T; Kaniwa, M; Kojima, S; Tsuda, M; Kurokawa, Y
HERO ID
1928219
Reference Type
Journal Article
Year
1994
Language
English
PMID
| HERO ID | 1928219 |
|---|---|
| In Press | No |
| Year | 1994 |
| Title | A new protocol and criteria for quantitative determination of sensitization potencies of chemicals by guinea pig maximization test |
| Authors | Nakamura, A; Momma, J; Sekiguchi, H; Noda, T; Yamano, T; Kaniwa, M; Kojima, S; Tsuda, M; Kurokawa, Y |
| Journal | Contact Dermatitis |
| Volume | 31 |
| Issue | 2 |
| Page Numbers | 72-85 |
| Abstract | This paper presents precise sensitization test data of 15 chemicals with a wide spectrum of sensitization potencies, and proposes a new protocol and criteria for quantitative evaluation of sensitization potencies of chemicals. The tests were performed according to the design of Magnus-son and Kligman, changing the application concentrations for induction as well as for challenge phases. 3-dimensional relationships between mean response (or sensitization rate), induction and challenge concentrations were found in all chemicals tested. The following 2 values are proposed as a quantitative measure of sensitization potency: (a) the minimum induction concentration that induces a positive response; (b) the challenge concentration that induces a mean response approximately equal to 1.0 among the animals applied with the highest concentration for induction. Both values coincided with each other within the range of 1 order of magnitude in every compound except 2. The values varied by 5 orders or more of magnitude among the compounds, showing a wide variation of sensitization potencies among chemicals. A good correlation was found for every chemical between the value of sensitization potency thus obtained and the residual levels in causative products in human cases of allergic contact dermatitis. A new experimental protocol for obtaining values (a) and (b) is proposed. |
| Doi | 10.1111/j.1600-0536.1994.tb01921.x |
| Pmid | 7750272 |
| Wosid | WOS:A1994NY58700002 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028174897&doi=10.1111%2fj.1600-0536.1994.tb01921.x&partnerID=40&md5=ddfdb9c69ace5d25155ddf47c28ef74b |
| Is Public | Yes |
| Language Text | English |
| Keyword | sensitization potency; quantitative evaluation; guinea pig maximization test; allergic contact dermatitis |