Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite
Derin, N; Akpinar, D; Yargicoglu, P; Agar, A; Aslan, M
| HERO ID | 1930165 |
|---|---|
| In Press | No |
| Year | 2009 |
| Title | Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite |
| Authors | Derin, N; Akpinar, D; Yargicoglu, P; Agar, A; Aslan, M |
| Journal | Neurotoxicology and Teratology |
| Volume | 31 |
| Issue | 1 |
| Page Numbers | 34-39 |
| Abstract | This study aimed to investigate the effect of alpha-lipoic acid (LA) administration on sulfite-induced alterations in visual evoked potentials (VEPs). Fifty two male albino Wistar rats were randomized into four experimental groups as follows; control (C), LA treated (L), sodium metabisulfite (Na(2)S(2)O(5)) treated (S), Na(2)S(2)O(5)+LA treated (SL). Na(2)S(2)O(5) (260 mg/kg/day) and LA (100 mg/kg/day) were given by intragastric intubation for 5 weeks. The latencies of VEP components were significantly prolonged in the S group and returned to control levels following LA administration. Thiobarbituric acid reactive substances (TBARS) levels in the S group were significantly higher than those detected in controls. LA significantly decreased brain and retina TBARS levels in the SL group compared with the S group. Sulfite caused a significant decrease in retina and brain glutathione peroxidase (GPx) activities which was restored to control levels via LA administration. Brain glutathione (GSH):glutathione disulfide (GSSG) ratio was significantly increased in rats jointly treated with sulfite and LA compared to rats treated with sulfite alone. Though not significant, a similar increase in GSH:GSSG ratio was also observed in the retina of SL group. This study showed that LA is protective against sulfite-induced VEP alterations and oxidative stress in the brain and retina. (C) 2008 Elsevier Inc. All rights reserved. |
| Doi | 10.1016/j.ntt.2008.08.002 |
| Pmid | 18761084 |
| Wosid | WOS:000262888600005 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Keyword | Alpha-lipoic acid; Oxidative stress; Sulfite; Visual evoked potentials |