Sulfur dioxide: A novel gaseous signal in the regulation of cardiovascular functions
Liu, D; Jin, H; Tang, C; Du, J
HERO ID
1932140
Reference Type
Journal Article
Subtype
Review
Year
2010
Language
English
PMID
| HERO ID | 1932140 |
|---|---|
| Material Type | Review |
| In Press | No |
| Year | 2010 |
| Title | Sulfur dioxide: A novel gaseous signal in the regulation of cardiovascular functions |
| Authors | Liu, D; Jin, H; Tang, C; Du, J |
| Journal | Mini - Reviews in Medicinal Chemistry |
| Volume | 10 |
| Issue | 11 |
| Page Numbers | 1039-1045 |
| Abstract | The atmospheric pollutant sulfur dioxide (SO(2)) is endogenously generated from the normal metabolism of sulfur-containing amino acids through the aspartate aminotransferase pathway. SO(2) is produced in cardiovascular tissues, and the aspartate aminotransferase mRNA is localized in endothelia and in vascular smooth muscle cells near the endothelial layer. Recent studies explored the physiological and pathophysiological effects of endogenous SO(2) on the cardiovascular system, and various potential mechanisms were found. These discoveries suggest a novel role of endogenous SO(2) in the modulation of the cardiovascular system and provide a basis for new treatments for cardiovascular diseases. |
| Doi | 10.2174/1389557511009011039 |
| Pmid | 20540708 |
| Wosid | WOS:000285417600004 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Cardiovascular; gaseous signal; sulfur dioxide; pathophysiology; physiology; toxicology; Cardiovascular tissues; Aminotransferase mRNA; Vascular smooth muscle; Endothelial layer; Sulfur dioxide (SO2); Hydrogen sulfide (H2S); Pollutant gas; Antimicrobial agent; Antioxidant; Methionine; Cysteine; Cystine; Homocysteine; Cysteinesulfinate decarboxylase (CSD); Highperformance liquid chromatography; Cardiac dysrhythmia; Regulating apoptosis- related genes; Vasorelaxant effect; Systolic blood pressure; Pulmonary hypertension (PH); Vascular inflammation; Kinase/mitogen-activated; Myocardial malondialdehyde; Butterfly effect |