Embryo-toxicity and fetotoxicity of inhaled carbon-tetrachloride, 1,1-dichloroethane and methyl ethyl ketone in rats
Leong, BKJ; Schwetz, BA; Gehring, PJ
HERO ID
1937675
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 1937675 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Embryo-toxicity and fetotoxicity of inhaled carbon-tetrachloride, 1,1-dichloroethane and methyl ethyl ketone in rats |
| Authors | Leong, BKJ; Schwetz, BA; Gehring, PJ |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 123 |
| Abstract | The effects of subanesthetic concentrations of carbon tetrachloride (300 and 1000 ppm), 1,1-dichloroethane (3800 and 6000 ppm) and methyl ethyl ketone (1000 and 3000 ppm) on rat embryonal and fetal development have been studied. Groups of pregnant Sprague-Dawley rats were exposed to each solvent 7 hr/day on days 6 through 15 of gestation. All 3 solvents caused some degree of retarded fetal development, such as delayed ossification of sternebrae. Methyl ethyl ketone caused, in addition to the aforementioned embryotoxicity, a low incidence of true terata (acaudia, imperforate anus and brachygnathia) at 3000 ppm. These studies did not reveal a correlation between the toxicity incurred by the mother exposed to these solvents and that incurred by the embryos or fetuses. |
| Wosid | WOS:A1974T653800128 |
| Url | https://www.proquest.com/scholarly-journals/embryo-fetotoxicity-inhaled-carbon-tetrachloride/docview/82472701/se-2?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Comments | Journal: ISSN: |
| Is Public | Yes |
| Language Text | English |
| Keyword | Hydrocarbons, Chlorinated; Ketones; Solvents; Alanine Transaminase; EC 2.6.1.2; L99N5N533T; Index Medicus; Abnormalities, Drug-Induced -- etiology; Chemical and Drug Induced Liver Injury -- enzymology; Solvents -- poisoning; Alanine Transaminase -- blood; Organ Size; Pregnancy; Animals; Liver -- drug effects; Time Factors; Eating -- drug effects; Ethane -- poisoning; Embryo, Mammalian -- drug effects; Fetus -- drug effects; Hydrocarbons, Chlorinated -- poisoning; Carbon Tetrachloride Poisoning; Ketones -- poisoning |
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