Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids
Diaz Gomez, MI; Castro, JA
HERO ID
194790
Reference Type
Journal Article
Year
1980
Language
English
PMID
| HERO ID | 194790 |
|---|---|
| In Press | No |
| Year | 1980 |
| Title | Covalent binding of carbon tetrachloride metabolites to liver nuclear DNA, proteins, and lipids |
| Authors | Diaz Gomez, MI; Castro, JA |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 56 |
| Issue | 2 |
| Page Numbers | 199-206 |
| Abstract | Abstract: super(1) super(4)C from super(1) super(4)CCl sub(4) irreversibly bind in vivo) to liver DNA from strain A/J mice and Sprague-Dawley rats. Binding of super(1) super(4)CCl sub(4) to DNA was also observed in vitro) in incubation mixtures containing microsomes and a NADPH-generating system as well as in tissue slices. Chemically induced multiplied by CCl sub(3) (CCl sub(4) + benzoyl peroxide system) intensively binds to DNA. Liver nuclear proteins also irreversibly bind CCl sub(4) metabolites. Nuclear protein fractionation studies revealed that deoxyribonucleoproteins, acidic proteins, histones, and residual proteins are the favorite targets of metabolite interaction. Nuclear sap proteins are less intensively labeled. Nuclear lipids were markedly labeled by CCl sub(4) reactive metabolites. Most of the label is in the phospholipid fraction and diphosphatidylglycerol is most intensively labeled; phosphatidylethanolamine, phosphatidylcholine, lysophosphatidylcholine, and sphingomyeline are also labeled by metabolites. ds: carbon tetrachloride evised - 2006-11-01 e field[29]: 1,4-Dioxane |
| Pmid | 7466819 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |