Effects of starvation and protein deficiency on the acute carbon tetrachloride-induced hepatotoxicity
Yoshimine, K; Takagi, M
| HERO ID | 195116 |
|---|---|
| In Press | No |
| Year | 1982 |
| Title | Effects of starvation and protein deficiency on the acute carbon tetrachloride-induced hepatotoxicity |
| Authors | Yoshimine, K; Takagi, M |
| Journal | Bulletin of Tokyo Medical and Dental University |
| Volume | 29 |
| Issue | 2 |
| Page Numbers | 37-46 |
| Abstract | The effects of starvation and protein-deficient diet on the acute carbon tetrachloride (CCl4)-induced hepatotoxicity of the mice were studied histologically and histochemically. A total of 69 male mice (C57BL/6) were used and carbon tetrachloride was administered by a single subcutaneous injection at a dose of 0.1 mg/10 g body weight after starvation for 24 hours and feeding with protein-deficient diet for one month. The changes were examined consecutively. It was shown the the CCl4-induced hepatotoxicity was exaggerated by starvation and that the regeneration after centrilobular necrosis due to CCl4 administration was retarded under this condition. In the CCl4-treated group on protein-deficient diet, the centrilobular liver cells seemed to be less responsive to CCl4. |
| Pmid | 6961968 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Is Qa | No |