Short-term inhalation test for evaluating industrial hepatotoxicants in rats
Brondeau, MT; Bonnet, P; Guenier, JP; De, CJ
HERO ID
200247
Reference Type
Journal Article
Year
1983
Language
English
PMID
| HERO ID | 200247 |
|---|---|
| In Press | No |
| Year | 1983 |
| Title | Short-term inhalation test for evaluating industrial hepatotoxicants in rats |
| Authors | Brondeau, MT; Bonnet, P; Guenier, JP; De, CJ |
| Journal | Toxicology Letters |
| Volume | 19 |
| Issue | 1-2 |
| Page Numbers | 139-146 |
| Abstract | Liver damage was investigated in rat using serum enzyme activities measurements. Responses were recorded 24 h after whole body inhalation exposure to vapors of bromobenzene, carbon tetrachloride, chloroform, o-dichlorobenzene, 1,2-dichloroethane and dimethylformamide as model toxicants. First, rats were exposed during a single 4 h period to different concentrations of each solvent and the minimally active concentration was determined. Second, repeated exposures to chemicals at this concentration level (6 h daily, 2 or 4 days) were used in order to examine whether hepatotoxicity was enhanced. GLDH and SDH are more sensitive and more constant indices than GOT and GPT. It appears that a single exposure period induced more marked serum activities enhancement than repeated exposures |
| Doi | 10.1016/0378-4274(83)90274-6 |
| Pmid | 6658818 |
| Wosid | WOS:A1983RS79300021 |
| Url | https://search.proquest.com/docview/80836101?accountid=171501 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | N1-Short-term inhalation test for evaluating industrial hepatotoxicants in ratsN1-DA - 19840214IN FILEL-Iditol 2-DehydrogenaseLiverLiver DiseasesMaleRatsRats,Inbred StrainsSolventstoxicityID-73 |
| Is Public | Yes |
| Language Text | English |
| Keyword | GLDH; glutamate deshydrogenase; GOT; glutamic oxaloacetic transaminase; GPT; glutamic pyruvic transaminase; SHD; sorbitol deshydrogenase |
| Relationship(s) |
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