A review of the terms agglomerate and aggregate with a recommendation for nomenclature used in powder and particle characterization

Nichols, G; Byard, S; Bloxham, MJ; Botterill, J; Dawson, NJ; Dennis, A; Diart, V; North, NC; Sherwood, JD

HERO ID

202114

Reference Type

Journal Article

Subtype

Review

Year

2002

Language

English

PMID

12226837

HERO ID 202114
Material Type Review
In Press No
Year 2002
Title A review of the terms agglomerate and aggregate with a recommendation for nomenclature used in powder and particle characterization
Authors Nichols, G; Byard, S; Bloxham, MJ; Botterill, J; Dawson, NJ; Dennis, A; Diart, V; North, NC; Sherwood, JD
Journal Journal of Pharmaceutical Sciences
Volume 91
Issue 10
Page Numbers 2103-2109
Abstract The terms agglomerate and aggregate are widely used by powder technologists to describe assemblages of particles that are found in dry powders and powders in liquid suspensions. Each term has a specific meaning but, unfortunately, they are frequently interchanged at will and this has resulted in universal confusion. This confusion is perpetuated by conflicting definitions in national and international standards and this presents problems when describing powder properties or communicating results in reports and research papers. This paper reviews the current status of the definitions, with particular emphasis on their use in the pharmaceutical industry. It is proposed that just one term, agglomerate, should be used to describe an assemblage of particles in a powder and that the term aggregate should be confined to pre-nucleation structures. © 2002 Wiley-Liss Inc. and the American Pharmaceutical Association J Pharm Sci 91:2103-2109, 2002
Doi 10.1002/jps.10191
Pmid 12226837
Is Certified Translation No
Dupe Override No
Is Public Yes
Language Text English
Keyword Agglomerate; aggregate; nomenclature; particle assemblage; powder characterization; powder properties
Is Qa No