An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma
Lupo, PJ; Lee, LJ; Okcu, MF; Bondy, ML; Scheurer, ME
HERO ID
2128169
Reference Type
Journal Article
Year
2012
Language
English
PMID
| HERO ID | 2128169 |
|---|---|
| In Press | No |
| Year | 2012 |
| Title | An exploratory case-only analysis of gene-hazardous air pollutant interactions and the risk of childhood medulloblastoma |
| Authors | Lupo, PJ; Lee, LJ; Okcu, MF; Bondy, ML; Scheurer, ME |
| Journal | Pediatric Blood & Cancer |
| Volume | 59 |
| Issue | 4 |
| Page Numbers | 605-610 |
| Abstract | <strong>BACKGROUND: </strong>There is evidence that exposure to chlorinated solvents may be associated with childhood medulloblastoma and primitive neuroectodermal tumor (M/PNET) risk. Animal models suggest genes related to detoxification and DNA repair are important in the carcinogenicity of these pollutants; however, there have been no human studies assessing the modifying effects of these genotypes on the association between chlorinated solvents and childhood M/PNET risk.<br /><br /><strong>PROCEDURE: </strong>We conducted a case-only study to evaluate census tract-level exposure to chlorinated solvents and the risk of childhood M/PNET in the context of detoxification and DNA repair genotypes. Cases (n = 98) were obtained from Texas Children's Hospital and MD Anderson Cancer Center. Key genotypes (n = 22) were selected from the Illumina Human 1M Quad SNP Chip. Exposure to chlorinated solvents (methylene chloride, perchloroethylene, trichloroethylene, and vinyl chloride) was estimated from the US EPA's 1999 Assessment System for Population Exposure Nationwide (ASPEN). Logistic regression was used to estimate the case-only odds ratios and 95% confidence intervals (CIs).<br /><br /><strong>RESULTS: </strong>There were 11 significant gene-environment interactions associated with childhood M/PNET risk. However, after correcting for multiple comparisons, only the interaction between high trichloroethylene levels and OGG1 rs293795 significantly increased the risk of childhood M/PNET risk (OR = 9.24, 95% CI: 2.24, 38.24, Q = 0.04).<br /><br /><strong>CONCLUSIONS: </strong>This study provides an initial assessment of the interaction between ambient levels of chlorinated solvents and potentially relevant genotypes on childhood M/PNET risk. Our results are exploratory and must be validated in animal models, as well as additional human studies. |
| Doi | 10.1002/pbc.24105 |
| Pmid | 22389292 |
| Wosid | WOS:000307386300003 |
| Url | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864960881&doi=10.1002%2fpbc.24105&partnerID=40&md5=170766dff39f775b8b3c1793869b92bd |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Pediatric blood & cancer ISSN: 1545-5017 |
| Is Public | Yes |
| Language Text | English |
| Keyword | childhood medulloblastoma and primitive neuroectodermal tumor; chlorinated solvents; detoxification genes; DNA repair genes; hazardous air pollutants |