Studies of the carcinogenicity of an acetone extract of hashish
Procter, BG; Dussault, P; Rona, G; Chappel, CI
HERO ID
2143566
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2143566 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Studies of the carcinogenicity of an acetone extract of hashish |
| Authors | Procter, BG; Dussault, P; Rona, G; Chappel, CI |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 76 |
| Abstract | Four experiments were carried out in laboratory animals in an effort to obtain information which might indicate possible carcinogenicity associated with the use of hashish by man. All studies were conducted using an acetone extract of crude hashish which contained 2.4% Δ9-tetrahydrocannabinol. The extract was investigated in a long-term skin painting study in mice and was also incorporated into cholesterol-based pellets whose carcinogenicity was studied in Inice using a bladder implantation technique. The hashish extract was not carcinogenic in either of these studies. In further investigations, the extract did not prove to be a tumor "initiator", but as a tumor "promoter" it was at least as potent as croton oil. Thus, systematic ante mortem observation of developing skin tumors and post mortem microscopic study of representative tumors revealed that, following initiation with dimethylbenzanthracene, the hashish extract caused the development of a high incidence of multiple benign fibroepithelial and papillomatous neoplasms. This same effect was associated with croton oil but the tumors produced were noticeably fewer. On the other hand, malignancy was a relatively common attribute of the skin tumors that developed during croton oil administration, but very few malignant skin tumors developed in the animals treated with the hashish extract. (Supported by the Non-Medical Use of Drugs Directorate, Health & Welfare, Canada.) |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Comments | Scopus URL: https://www.scopus.com/inward/record.uri?eid=2-s2.0-18844463474&partnerID=40&md5=0a16a1bd2c23efd29cb081a99d33e9ff |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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