Further investigations of the capacity of polynuclear aromatic hydrocarbons to elicit atherosclerotic lesions
Bond, JA; Gown, AM; Yang, HL; Benditt, EP; Juchau, MR
HERO ID
2145017
Reference Type
Journal Article
Year
1981
Language
English
PMID
| HERO ID | 2145017 |
|---|---|
| In Press | No |
| Year | 1981 |
| Title | Further investigations of the capacity of polynuclear aromatic hydrocarbons to elicit atherosclerotic lesions |
| Authors | Bond, JA; Gown, AM; Yang, HL; Benditt, EP; Juchau, MR |
| Journal | Journal of Toxicology and Environmental Health |
| Volume | 7 |
| Issue | 2 |
| Page Numbers | 327-335 |
| Abstract | Treatment of chickens for up to 20 weeks with 0.1,1.0, and 10mg/kg doses of benzo(a)pyrene (BaP) or 7,12-dimethylbenz(a)anthracene (DMBA) resulted in significant increases in incidence and size of atherlosclerotic lesions at the 2 higher doses. Maximal lesion formation for birds treated chronically with BaP occurred at 1mg/kg and development of lesions in birds treated with DMBA was roughly linear over the dose range. Administration of 10mg/kg for 20 weeks of BaP or DMBA produced lesions in 75 and 89% respectively of chickens. Lower doses of BaP or DMBA produced smaller percentages of lesions, and the 0.1mg/kg dose produced no increase in lesion incidence. At equimolar doses DMBA was more potent than BaP. Administration of a single dose of BaP or DMBA followed by weekly doses of 12-0-tetradecanoylphorbol 13-acetate (TPA) for 20 weeks did not result in enhancement of lesion formation. Blood cholesterol was not significantly altered after treatment with BaP, DMBA or TPA. |
| Doi | 10.1080/15287398109529983 |
| Pmid | 6262518 |
| Wosid | WOS:A1981LF55300014 |
| Is Certified Translation | No |
| Dupe Override | No |
| Comments | Journal: Journal of Toxicology and Environmental Health Feb ISSN: |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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