Histologic response of mouse urinary bladder to 2-acetylaminofluorene in a large subacute experiment
Jaques, WE; Frith, CH
HERO ID
2147643
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2147643 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Histologic response of mouse urinary bladder to 2-acetylaminofluorene in a large subacute experiment |
| Authors | Jaques, WE; Frith, CH |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 105 |
| Abstract | These studies are concerned with the premalignant and pathogenetic factors in chemically induced injury to the mouse uroepithelium. One thousand, two hundred mice equally divided between the C57BL/6j and BALB/cSt/BR strain equally sexed and weighing from 17 to 31 g were fed dietary 2-AAF for 90 days. The mice were divided and fed 2-AAF concentrations of 0.05, 0.25, 0.01, 0.005 and 0.001%, respectively. There were 240 control animals. Complete necropsies were performed at sacrifice but significant change were observed only in the urinary bladder. The transitional cell epithelium displayed progressive thickening from the usual 3-4 cell layer. This degree of hyperplasia was quantitated into 3 grades. Squamous metaplasia was a significant feature in many of the mice. Two examples of overt neoplasia of the urinary bladder occurred with one being in situ and the other demonstrating early invasiveness. Dietary levels of 0.01-0.05% gave a 100% response. The studies support the concept of hyperplasia which may precede neoplasia and squamous metaplasia being a prerequisite for squamous carcinoma of the urinary bladder. |
| Wosid | WOS:A1974T653800084 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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