Histopathologic changes in mice fed 2-acetylaminofluorene (2-AAF) in a chronic study
Frith, CH; Jaques, WE
HERO ID
2147647
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2147647 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Histopathologic changes in mice fed 2-acetylaminofluorene (2-AAF) in a chronic study |
| Authors | Frith, CH; Jaques, WE |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 106 |
| Abstract | This investigation concerns the histopathologic changes produced by feeding 2-acetylaminofluorene (2-AAF) to large numbers of mice in a chronic study. Beginning at weanling age, BALB/c and C57BL/6 mice of both sexes were fed 2-AAF in their diet for up to 18 months at concentrations of 0, 100, 250 and 500 ppm. Complete necropsies were performed on over 2000 animals that died or became ill and were sacrificed, and approximately 50 tissues from each mouse were studied histologically. Significant changes were observed in the urinary bladder and the liver. The changes in the bladder ranged from hyperplasia and squamous metaplasia of the transitional epithelium to carcinoma with extensive metastases. Bladder neoplasms included transitional cell carcinomas, transitional cell carcinomas with squamous metaplasia, squamous cell carcinomas and anaplastic carcinomas. Bladder tumors developed much earlier in the BALB/c mice than in the C57BL/6 mice and were more common in the female animals. A definite sex difference in the C57BL/6 mice was not established. Histopathologic changes in the liver included single or multiple hepatomas, some of which metastasized to the lungs. There was also an apparent increase in reticulum cell sarcoma. Bladder tumors, hepatomas, and reticulum cell sarcomas were noted in both sexes of both strains at all three concentrations of 2-AAF. A small number of hepatomas and reticulum cell sarcomas were noted in the controls, but bladder tumors were not found in untreated animals. |
| Wosid | WOS:A1974T653800086 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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