Tissue binding of [9-14C] 2-acetylaminofluorene in mice during oral administration
Jackson, CD; Weis, C; Shellenberger, TE
HERO ID
2147649
Reference Type
Journal Article
Subtype
Abstract
Year
1974
Language
English
| HERO ID | 2147649 |
|---|---|
| Material Type | Abstract |
| In Press | No |
| Year | 1974 |
| Title | Tissue binding of [9-14C] 2-acetylaminofluorene in mice during oral administration |
| Authors | Jackson, CD; Weis, C; Shellenberger, TE |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 29 |
| Issue | 1 |
| Page Numbers | 107 |
| Abstract | This study was made to determine the extent of tissue binding of 2-acetylaminofluorene (AAF) during oral administration of the carcinogen at different dose levels. Weanling, female BALB/cJ and C57BL/6J mice were maintained on diets containing 5 or 500 ppm [9-14C] AAF for 8 weeks. The amount of 14C bound to liver and bladder tissue, as well as blood concentrations, were determined at various intervals. Results obtained with the two dose levels were essentially parallel with amounts of 14C being approximately 100-fold higher in mice on the 500 ppm diet. Blood values of 14C in both strains of mice increased for 2 weeks and then remained constant with the concentrations in BALB/cJ mice being twice that of C57BL/6J mice on the same diet. Amounts of bound 14C in liver tissue also reached a plateau at 2 weeks and were approximately 40 % higher in C57BL/6J mice. In contrast, the amount of 14C bound to bladder tissue continued to increase over the entire 8-week period. In a second experiment, weanling, female BALB/cJ and C57BL/6J mice were maintained on diets containing AAF at various levels over the range of 0.5-500 ppm and sacrificed at the end of 2 weeks. Blood and tissue concentrations were determined as above. The results, plotted as log 14C bound vs log concentration of AAF in the diet, indicate that the amount of AAF bound to both liver and bladder tissue is linear over the dose range studied. |
| Wosid | WOS:A1974T653800088 |
| Is Certified Translation | No |
| Dupe Override | No |
| Conference Location | Washington, D.C. |
| Conference Name | Thirteenth Annual Meeting of the Society of Toxicology |
| Conference Date | March 10–14, 1974 |
| Is Public | Yes |
| Language Text | English |
| Relationship(s) |
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